A WellnessRx Education Initiative for Health Professionals: Its Evolution, Diffusion and Evaluation

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Previous studies reported that eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations are age-dependant but their kinetics are unknown. Objective: To determine the kinetics of 13C-EPA and 13C-AA in young and older participants. Method: Six young (18-30 yrs old) and six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA. Fasted blood samples were collected before breakfast (baseline) and thereafter at 2 h, 4 h, 6 h, 24 h, 7 d, 14 d, after the tracer intake. Preliminary results: The data presented here are on two young and six elderly participants. Mean age of the young and the elderly is 24 ± 4 and 75 ± 2 yrs old, respectively. At baseline, there was no difference in plasma triglycerides, and total cholesterol between the two groups supporting that the elderly were metabolically healthy. Plasma incorporation of 13C-EPA peaked within 6 h in both groups (2.0 ± 0.5 nmol/ml). 13C- AA peaked within 4-24 h in participants (3.2 ± 0.2 nmol/ml). After the 13C- EPA intake, the retroconversion of 13C-EPA into 13C-DHA was 17% higher in the elderly compared to the young. After the intake of 13C-AA, retroconversion into 13C-LA and 13C-DGLA was higher in the elderly potentially indicating a higher degradation rate with age. 13CO2 will be analyzed in the breath sample and will assess if β-oxidation of 13C-AA is higher in the elderly group. Conclusion: Older men had transiently higher EPA concentrations compared to younger adults. More studies are needed to evaluate whether the change in EPA kinetics is a «normal» physiological modification occurring during aging or whether it contributes to risk of developing diseases associated with aging such as low grade inflammation.

Speaker:
Pauline Léveillé, PhD
Pre. Mélanie Plourde's laboratory
University of Sherbrooke

***Original Source: "2016 CNS Annual Conference", Saturday, May 7, 2016

Length: 11:29

Type: Video

Last Updated: May 30, 2016