A WellnessRx Education Initiative for Health Professionals: Its Evolution, Diffusion and Evaluation
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Previous studies reported that eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations are age-dependant but their kinetics are unknown. Objective: To determine the kinetics of 13C-EPA and 13C-AA in young and older participants. Method: Six young (18-30 yrs old) and six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA. Fasted blood samples were collected before breakfast (baseline) and thereafter at 2 h, 4 h, 6 h, 24 h, 7 d, 14 d, after the tracer intake. Preliminary results: The data presented here are on two young and six elderly participants. Mean age of the young and the elderly is 24 ± 4 and 75 ± 2 yrs old, respectively. At baseline, there was no difference in plasma triglycerides, and total cholesterol between the two groups supporting that the elderly were metabolically healthy. Plasma incorporation of 13C-EPA peaked within 6 h in both groups (2.0 ± 0.5 nmol/ml). 13C- AA peaked within 4-24 h in participants (3.2 ± 0.2 nmol/ml). After the 13C- EPA intake, the retroconversion of 13C-EPA into 13C-DHA was 17% higher in the elderly compared to the young. After the intake of 13C-AA, retroconversion into 13C-LA and 13C-DGLA was higher in the elderly potentially indicating a higher degradation rate with age. 13CO2 will be analyzed in the breath sample and will assess if β-oxidation of 13C-AA is higher in the elderly group. Conclusion: Older men had transiently higher EPA concentrations compared to younger adults. More studies are needed to evaluate whether the change in EPA kinetics is a «normal» physiological modification occurring during aging or whether it contributes to risk of developing diseases associated with aging such as low grade inflammation.
Pauline Léveillé, PhD
Pre. Mélanie Plourde's laboratory
University of Sherbrooke
***Original Source: "2016 CNS Annual Conference", Saturday, May 7, 2016
Last Updated: May 30, 2016
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