Exercise and nutrition in the modulation of inflammation-driven diseases
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Dr. David Wright, Presentation Description
It is well established that exercise has profound effects on whole body glucose and lipid metabolism. Owing to the fact that it is the primary tissue involved in locomotion, a vast amount of research has focused on the effects of exercise on skeletal muscle. However, it is now appreciated that exercise also impacts adipose tissue immune and metabolic health. A challenging aspect in studying adipose tissue immuno-metabolism with exercise is divorcing the effects of changes in weight loss from the direct effects of exercise on adipose tissue health. The purpose of this talk will be to highlight work from my group, and others, highlighting the powerful effects of exercise, independent of weight loss, on adipose tissue health.
Omega-3 Fatty Acid Supplementation and Resistance Training in Older Adults
Sarcopenia is the loss of muscle mass that occurs during the aging process. We know that sarcopenia is multifactorial in causation and that one factor contributing to sarcopenia is chronic low grade inflammation. Research has indicated the potential for omega-3 fatty acids to act in an anti-inflammatory manner by modifying the eicosanoids produced. Research has also indicated the benefit of resistance training for improving skeletal muscle mass in older adults. We hypothesized that supplementing the regular diet with omega-3 fatty acids while completing a standardized resistance training program would result in a greater increase in lean tissue mass as compared to resistance training and supplementing with a placebo. With this in mind, we aimed to determine the effects of using two different types of omega-3 supplements (alpha-linolenic acid [ALA] and combined eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]) during a 12-week resistance training program on inflammatory cytokines and body composition in older adults in two separate interventions. In intervention #1 we used ALA supplementation (~14 grams/day) and found that while it did lower the inflammatory cytokine interleukin-6 there was no greater increase in lean tissue mass in the ALA supplemented group. In the second intervention we used a combined EPA/DHA supplement (~3.0 grams/day) but we failed to show a lowering of the inflammatory cytokines interleukin-6 and tumor necrosis factor-α and there was no greater increase in lean tissue mass when compared to the placebo. We conclude that at the doses we used the omega-3 fatty acids do not have anabolic potential.
***Original Source: "2017 Annual Conference", Friday, May 26, 2017
Last Updated: June 26, 2017
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