The role of 2'-FL in inflammation and its possible role in food allergy

Date:  Friday, September 9, 2022
Time: 12:00 - 13:00 ET

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Webinar description:

Human milk oligosaccharides (HMOs) are the most abundant solid component of human milk after lactose and lipids. Approximately 80% of mothers produce the HMO 2’ fucosylactose (2’FL). In this presentation we will review clinical studies exploring the immune benefit of 2’FL and discuss pre-clinical evidence of 2’FL on food allergy and potential mechanisms of action. We will describe the possible role of 2’FL HMO in enhancing oral tolerance.

Learning Objectives:

  1. To learn about HMOs, with a particular focus on 2’FL
  2. To learn about clinical studies supporting HMOs in immune support 
  3. To explore how 2’FL HMO may be relevant for nutritional management of infants with food allergy 
  4. To learn about the pre-clinical evidence of 2’FL effects on food allergy 
  5. To understand the effects of 2’FL on key elements of the immune response and their potential mechanisms of action

Paul Forsythe, PhD (University of Alberta) and Barbara Marriage, PhD, RD (Pediatric Nutrition Consultant) 

Moderator: Kyly Whitfield, PhD (Mount Saint Vincent University)

About the Speakers:

Barbara Marriage PhD RD -  Dr. Marriage is a consultant in pediatric nutrition and has considerable experience in both industry and clinical settings. Dr. Marriage held several positions within her 19 years at Abbott Nutrition and was most recently a Senior Associate Research Fellow, leading the Pediatric Nutrition Science and Innovation group, where she was responsible for clinical research and scientific support for pediatric products distributed globally.  
Other positions within Abbott included, Global Science Lead for Pediatric Specialty Nutrition, Associate Director in Global Regulatory Science and Innovation, as well as Manager of the Pediatric Clinical Nutrition group.
Before joining Abbott in 2002, Dr. Marriage worked for over 20 years as a clinical research dietitian with extensive experience in pediatric nutrition with an emphasis on the management of patients and families with inborn errors of metabolism.
Her research interests include human milk oligosaccharides, gastrointestinal disorders, allergy and inborn errors of metabolism. Dr Marriage has published over 30 articles in peer-reviewed journals, written book chapters and newsletters, and has given many presentations on nutrition related topics.

Paul Forsythe - Dr Paul Forsythe obtained his  PhD in Immunopharmacology at Queen’s University Belfast, UK. He then went on to pursue Post-Doctoral studies at the University of Alberta and McMaster University before becoming a faculty member in the Department of Medicine, McMaster University and Principal Investigator at the McMaster Brain-Body Institute. He joined the faculty of the University of Alberta as the AstraZeneca Canada Inc., Chair in Asthma and Obstructive Lung Disease in 2021. Dr Forsythe’s research falls within the field of psychoneuroimmunology; addressing cross-talk between components of the immune and nervous systems, and how such communication may influence the development of diverse pathophysiological responses such as inflammation, allergy and mood disorders. A major research focus is on the immunomodulatory and neuroactive properties of microbes and the role of the vagus nerve in bi-directional signalling between the immune system and the brain.

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